From Milan-Bologna: A14
to Cesena: exit Cesena nord, follow
E45 to Rome-Perugia exit Sansepolcro sud.
From Rome: A1 to Orte,
follow E45 Perugia-Cesena, exit Sansepolcro sud.
From Florence: "Autostrada del Sole"
A1, exit Arezzo, follow
directions
to Sansepolcro along SS 73.